CAS 54-11-5 L-Nicotine Colorless Volatile Liquid Irritating Odor 99% for Stimulant

L-Nicotine Of A Pale Yellow To Dark Brown, Oily Liquid Cas No 54-11-5

DESCRIPTION

Nicotine is the second most widely used recreational drug after caffeine. At low doses, nicotineacts as a stimulant to the central nervous system by activating acetylcholine receptors, specifically called nicotinic acetylcholine receptors, in the postsynaptic neurons during nerve transmission.At higher doses nicotine acts as a depressant.Nicotine in tobacco has always been used for medicinal purposes. Nicotine solutions made from soaking tobacco leaves in water have been used as pesticides for several hundred years. In modern times, numerous pharmaceutical companies have explored nicotine's use for treating diseases. Nicotine's most prevalent medicinal use is for smoking cessation in the form of alternate delivery systems such as gums and dermal patches. Nicotine is used medically for numerous conditions and its use is being explored in additional areas including pain relievers, attention deficit disorder medications and medications associated with Alzheimer's disease, Parkinson disease, colitis, herpes, and tuberculosis.

Medical use

Nicotine gum is a chewing gum containing a small dose of nicotine polacrilex.It is classified as a short-acting (also called fast-acting) form of NRT because it relieves the cravings and symptoms that occur with smoking cessation more quickly than a long-acting NRT (i.e., the nicotine patch). It can be used alone or in conjunction with other forms of pharmacotherapy for cessation of tobacco products.
The nicotine contained in nicotine gum is released with chewing and is absorbed through the lining of the mouth to enter the blood stream. Due to this fact, nicotine gum is not chewed like regular chewing gum, but follows a “chew and park” protocol: the gum is chewed slowly until a peppery taste or tingling sensation can be felt in the mouth; the gum is then “parked” and held between the gums and the inside of the cheek for about a minute until the tingling subsides; chewing is resumed when the tingling fades. This procedure repeats, occasionally changing where the gum is parked in the mouth, until the tingle can no longer be felt, usually about 30 minutes after starting.On account of its short-acting nature, nicotine gum requires repeated use throughout the day, and its reliance on chewing as the mechanism of nicotine release leads to more variable levels of nicotine in the blood than the patch.

Properties