Cas 80-70-6 1,1,3,3-Tetramethylguanidine Alkali Catalyst Drug Synthesis

1,1,3,3-Tetramethylguanidine As A Nonaqueous Solvent Cas 80-70-6​

DESCRIPTION

Tetramethylguanidine (TMG) is an organic compound with the molecular formula C6H12N2 and the structural formula N (CH3) 2C (NCH3) 2, belonging to the guanidine group. It is a colorless liquid with a pungent odor at room temperature, easily volatile, and soluble in solvents such as water, ethanol, and benzene.

Tetramethylguanidine is often used as an alkali catalyst in the chemical industry, as well as as as a corrosion inhibitor, solvent, redox catalyst, etc. It is also widely used in fields such as drug synthesis, polymer material preparation, and dye synthesis.

Specification

USES

The role of tetramethylguanidine in chemical reactions is mainly as a base catalyst, which can promote acid-base neutralization reaction and nucleophilic substitution reaction and other reactions. The specific mechanism of action is:

1. Neutralizing acidic catalysts: Tetramethylguanidine has lone pair electrons on its nitrogen atom, which can react with acidic catalysts such as sulfuric acid and hydrochloric acid to neutralize their acidity, making the reaction system more neutral and promoting the progress of the reaction.

2. Promote nucleophilic substitution: because tetramethylguanidine is strongly alkaline, it can make nucleophilic reagents in the reactants such as haloalkane easier to carry out nucleophilic substitution, thus accelerating the reaction.